Efek Ekstrak Metanol Daun Pucuk Merah Terhadap Kadar Glukosa Darah

Jajar Pramata Syari

Abstract


Blood glucose level is the amount of glucose in the blood. High blood glucose levels can be lowered with traditional plants such as red shoots. The leaves of the red shoots are commonly used as herbal medicine as antibacterial, antioxidant and antidiabetic. The content of flavonoid compounds, alkaloids, saponins, tannins, polyphenols found in red shoots is known to have antidiabetic activity. The purpose of this study was to explain the effect of giving red shoots leaf extract on blood glucose levels. The method used is the enzymatic method with a glucometer. This research methodology is a Quasi Experimental Design. The population and samples in this study were male (Mus musculus) mice, 2-3 months old and weighing 20-30 grams with 3 treatments, namely 200 mg/kgBW, 400 mg/kgBW, 600 mg/kgBW. The results of the Simple Linear Regression test for a dose of 200 mg/kgBW, a dose of 400 mg/kgBW and a dose of 600 mg/kgBW obtained p value = 0.000 < 0.05 then Ha is accepted, which means that there is a significant effect between red shoot leaf extract on levels of blood glucose.

Keywords


Antidiabetic, Red Shoot Leaves, Blood Glucose

Full Text:

PDF

References


Abdalrahim, F.A.A., Khalid, M.A., Salman, A.A., Mohammad, J.S., Zhari, I., Amin, M.S.A.M. (2012). Syzygium aromaticum extracts as good source of betulinic acid and potential anti-breast cancer.Braz. J. Pharmacog. 22, 335–343.

Agus, D., Fakultas, P. and Universitas, F. (2013) Tanaman Obat Keluarga TOGA, pp. 978–979.

Aisha, A.F.A., Ismail Z., Salah, K.M.A.,Shiddiqui, J.M., Gafar, G., andMajid A.M.S.A. (2013). Syzygium campanulatum Korth methanolicextract inhiits angiogenesis andtumor growth in nude mice. BMC Complementary and Alternative Medicine. 13:168-178.

Andrie, M., Taurina, W. and Ayunda, R. (2014) ‘Uji Aktivitas Jamu Gendong Kunyit Asam (Curcuma domestica Val.;Tamarindus indica L.) Sebagai Antidiabetes Pada Tikus Yang DiInduksi Streptozotocin’, Traditional Medicine Journal, 19(2), pp. 95–102.

Arai, Y., Watanabe, S., Kimira, M., Shimoi, K., Mochizuki, R., Kinae, N. (2000) Dietary intakes offlavonols, flavones and isoflavones by Japanese women and the inverse correlation betweenquercetin intake and plasma LDL cholesterol concentration. J. Nutr. 130: 2243–2250.

Banu, K. S. and Cathrine, L. (2015) ‘General Techniques Involved in Phytochemical Analysis’, International Journal of Advanced Research in Chemical Science (IJARCS), 2(4), pp. 25–32.

BPOM (2014) ‘Peraturan Kepala Badan Pengawas Obat Dan Makanan Republik Indonesia Nomor 7 Tahun 2014; Pedoman Uji Toksisitas Nonklinik Secara In Vivo’.

Brahmachari, G. 2011, Bio-flavonoids with promising antidiabetic potentials: a critical survey, Research Signpost, 187-212.

Dafriani, P., Andika, H. and Hanifa, Y. (2018) ‘Pengaruh Rebusan Daun Salam Terhadap Penurunan Kadar Gula Darah Pada Pasien Diabetes Mellitus Tipe II Di Wilayah Kerja Puskesmas Alai Padang’, Jurnal Kesehatan Saintika Meditory, 1(1), pp. 53–63.

Departemen Kesehatan RI (2000) Parameter Standar Umum Ekstrak Tanaman Obat. Direktorat Jendral Pengawasan Obat: Jakarta.

Djipa, C.D., Delmée, M., Quetin-Leclercq, J. (2000) Antimicrobial activity of bark extracts ofSyzygium Jambos (L.) Alston (Myrtaceae). J. Ethnopharmacol. 71: 307–313.

Firdaus, M. (2017) Diabetes dan Rumput Laut Coklat. Edited by Tim UB Press. UB Press: Malang.

Hanani, E. (2017) Analisis Fitokimia. Penerbit Buku Kedokteran EGC : Jakarta.

Hayati, M., Hamzah, Z. and H, A. T. W. (2020) ‘Hubungan Kadar Insulin Pankreas dan Kadar Glukosa Darah pada Model Tikus Wistar Jantan setelah Diinduksi Bisphenol-A’, Stomatognatic-Jurnal Kedokteran Gigi, 17(1), pp. 4–7.

Irianto, K. (2006) Mikrobiologi. Alfabeta: Bandung.

Jack. 2012. Synthesis of antidiabetic falavonoids and their derivatives. Master’s Thesis. Tianjin University.

Jems, A. and unitly, A. (2012) ‘Keadaan Puasa Terhadap Kadar Glukosa Darah Tikus Rattus Norvegicus’, Jurnal Edukasi dan Sains Biologi, 1(1), p. 77133.

Kshanti, I. A. (2019) Pedoman Pemantauan Glukosa Darah Mandiri. PB Perkeni: Jakarta.

Kim, H.M.; Lee, E.H., Hong, S.H., Song, H.J., Shin, M.K., Kim, S.H., Shin, T.Y. (1998) Effect ofSyzygium aromaticum extract on immediate hypersensitivity in rats. J. Ethnopharmacol. 60:125–131.

Leba, M. A. U. (2017) Buku Ajar Ekstraksi dan Real Kromatografi. Deepublish: Yogyakarta.

Maulana, M. (2015) Mengenal diabetes melitus. Katahati: Yogyakarta.

Memon, A.H., Ismail, Z., Al-Suede, F.S.R.,Aisha, A.F.A., Hamil, M.S.R.,Hashim, S., Saeed, M.A.A., et al.,. (2014). Isolation, Characterization, Crystal Structure Elucidation, and Anticancer Study of Dimethyl Cardamonin, Isolated from Syzygium campanulatum Korth. Evidence-Based Complementary and Alternative Medicine. 1-11.

Mir, Q.Y., Ali, M., Alam, P. (2009).Lignan derivatives from the stem bark of Syzygium cumini (L.) Skeels.Nat. Prod. Res. 23, 422–430.

Muruganandan, S., Srivastava, K., Chandra, S., Tandan, S.K., Lal, J., Raviprakash, V. (2001). Anti-inflammatory activity of Syzygium cumini bark. Fitoterapia. 72, 369–375.

Nur Aini,dkk, “Uji Toksisitas dan Aktivitas Antibakteri Ekstrak Daun Merah Tanaman Pucuk Merah (Syzigium mortifilium Walp.) Terhadap Bakteri Staphilococcus aureus dan Escherichia coliâ€. Jurnal Kimia Mulawarman, Vol. 13 No. 1, ( 2015), h.35.

Nugraheni, E. et al. (2011) Perbandingan Efek Peningkatan Kadar Gula Darah Antara Konsumsi Teh Manis Dan Kurma Saat Puasa Pada Usia Dewasa Muda. Bidang Ilmu Kesehatan: Bandung.

Pasaribu, F., Sitorus, P. and Bahri, S. (2012) ‘Uji Ekstrak Etanol Kulit Buah Manggis ( Garcinia mangostana L .) Terhadap Penurunan Kadar Glukosa Darah’, Journal of Pharmaceutics and Pharmacology, 1(1), pp. 1–8.

Perkeni (2019) Pedoman Pemantauan Glukosa Darah Mandiri 2019. PB Perkeni: Jakarta.

Prasetyowati, E. B., Pakki, S. G. and Dkk (2015) Pedoman Pengendalian Tikus Dan Mencit. Kementrian Kesehatan RI: Jakarta.

Prasmewari, O. M. and Widjanarko, S. B. (2014) ‘Uji Efek Ekstrak Air Daun Pandan Wangi Terhadap Penurunan Kadar Glukosa Darah Dan Histopatologi Tikus Diabetes Mellitus’, Jurnal Pangan dan Agroindustri, II(2), pp. 16–27.

Prizka, P. and Dwita, O. (2016) ‘Manfaat Daun Insulin (Smallanthus sonchifolius ) sebagai Antidiabetes’, Jurnal majority, 5(4), pp. 133–137.

Putra, W. S. (2015) Kitab Herbal Nusantara. Edited by Andien. yogyakarta: KATAHATI.

Ramadani, F. H., Intannia, D. and Ni’mah, M. (2016) ‘Profil Penurunan Kadar Glukosa Darah Ekstrak Air Rambut Jagung ( Zea Mays L .) Tua dan Muda Pada Mencit Jantan Galur Balb-C’, Jurnal Pharmascience, 3(1), pp. 37–44.

Retno Juwita, Chairul Saleh, dan Saibun Sitorus, (2017), “Uji Aktovitas Antihiperurisemia Dari Daun Hijau Tanaman Pucuk Merah (Syzygium myrtifolium Walp.) terhadap Mencit Jantan (Mus musculus)â€. Jurnal Atomik Vol 2 No. 1 hal. 162-168, h. 162.

Ridwan, A., Astrian, R. T. and Barlian, A. (2012) ‘Pengukuran Efek Antidiabetes Polifenol (Polyphenon) Berdasarkan Kadar Glukosa Darah dan Histologi Pankreas Mencit (Mus musculus L.) S.W. Jantan yang Dikondisikan Diabetes Mellitus’, Jurnal Matematika & Sains, 17(2), pp. 78–82.

Samy, M.N., Sugimoto, S., Matsunami, K., Otsuka, H., Kamel, M.S. (2014). One new flavonoid xylosideand one new natural triterpene rhamnoside from the leaves of Syzygium grande. Phytochem. Lett.10, 86–90.

Sasmita, F. W. et al. (2017) ‘Efek Ekstrak Daun Kembang Bulan (Tithonia diversifolia) terhadap Kadar Glukosa Darah Tikus Wistar (Rattus norvegicus) yang Diinduksi Alloxan’, Jurnal Biosfera, 34(1), pp. 22–31.

Syilfia Hasti, Emrizal, Folas Susilawati (2016) Uji Aktivitas Antidiabetes Ekstrak n-Heksana Daun Pucuk Merah (Syzygium myrtifolium Walp.) Terhadap Mencit Putih Diabetes. Jurnal Pharmacy. Vol.13 No. 02 Desember 2016 ISSN 1693-3591

Simatupang, R. (2020) Pedoman Diet Penderita Diabetes Melitus. Yayasan Pendidikan dan Sosial Indonesia Maju: Banten.

Smith, M. D. (2005) User’s Guide to Preventing & Reversing Diabetes Naturally : Mengenali Cara Memanfaatkan Makanan dan Suplemen Sebagai Perlindungan Terhadap Gangguan Gula Darah". (diterjemahkan oleh : Sinardy Susilo), Bhuana Ilmu Populer: Jakarta.

Stanely, M.P., Menon, V.P., Pari, L. (1998) Hypoglycaemic activity of Syzigium cumini seeds: Effect onlipid peroxidation in alloxan diabetic rats. J. Ethnopharmacol. 61, 1–7.

Sugiyono (2019) Metode Penelitian Kuantitatif Kualitatif dan R&D. Alfabeta: Bandung.

Tandra, H. (2013) Life Healthy With Diabetes. Rapha: Yogyakarta.

Wulandari (2016) ‘Uji Efektivitas Antihiperglikemia Kombinasi Jus Pare (Momordica charantia L) dan Jus Tomat (Solanum lycopersicum L) pada Tikus Wistar Jantan dengan Metode Toleransi Glukosa’, Pharmaceutical Sciences and Research, 3(3), pp. 145–154




DOI: https://doi.org/10.30602/jlk.v6i1.1109

Article Metrics

Abstract views : 248| PDF views : 52

Refbacks

  • There are currently no refbacks.


Copyright (c) 2022 Jurnal Laboratorium Khatulistiwa

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.